Role of G protein-associated membrane receptors in the pathogenesis of osteoporosis

Osteoporosis is a chronic disease characterized by pathological change in bone tissue, excessive fragility and decrease strength as result of the predominance resorption processes over process formation. This manifests form low-traumatic fractures occurring falling from height one’s height, or with little physical exertion. could vertebral bodies bones peripheral skeleton, causing high level disability. Of note, postmenopausal osteoporosis develops women against background cessation menstrual cycle. Here we overview role G-protein-associated membrane receptors (GPCR family) pathogenesis this prospects for finding targets among these diagnosis treatment osteoporosis. Malformations genes encoding GPCR lead to impaired tissue remodeling. Exploring functions family members critical search predisposition markers dysfunction improve early Studies on model osteoblasts differentiated hIPSCs obtained patients associated mutations will allow deeper understanding molecular nature identification new treatment.